Ouzaid I, Panthier F, Hermieu JF, Xylinas E. ![]() Diagnosis and treatment of bladder cancer: how can we improve? Postgrad Med. Urinary VOC analysis could aid the diagnosis and surveillance of UBC. A six-VOC surveillance biomarker panel obtained AUROC 0.80 (sensitivity 0.71 and specificity 0.80). An eight-VOC diagnostic biomarker panel achieved AUROC 0.77 (sensitivity 0.71, specificity 0.72). Two prediction models were evaluated using internal validation. Ten VOCs had statistically significant abundances useful to classify patients (false discovery rate range 1.9 × 10 -7-2.8 × 10 -2). A distinctive VOC profile was observed in UBC patients compared with controls. In the surveillance group, 75 had recurrent UBC, 84 were recurrence-free. Of the haematuria patients, 21 had a new UBC diagnosis, 125 had no cancer. The median participant age was 70 years, 66.2% were male. ![]() Urinary headspace sampling utilised solid-phase microextraction and VOC analysis applied gas chromatography-mass spectrometry the output underwent metabolomic analysis. Urine samples were collected from haematuria clinic patients undergoing diagnostic cystoscopy and UBC patients undergoing surveillance. ![]() This cross-sectional study compared the VOC profiles of patients with and without UBC, to investigate metabolomic signatures as biomarkers. There is a need for biomarkers to reduce the frequency of cystoscopy in surveillance urinary volatile organic compound (VOC) analysis could fulfil this role. The diagnosis and surveillance of urothelial bladder cancer (UBC) require cystoscopy.
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